National Institute on Aging Concepts
Synapse: Registration Open
Neuroscience News keeps you updated on interesting clinical and translational neuroscience events and funding opportunities. Make sure to visit the IHSI website for all the latest health research news and grant information for Illinois investigators and collaborators.
As always, if you have an event or announcement to share with the neuroscience community at Illinois, we are happy to include it here. Email Gillian Cooke, IHSI research development manager, with your item.
Cancer Treatment-Related Cognitive Impairment | SUBMIT YOUR PROPOSAL NOW
As the number of cancer survivors in the U.S. increases—from the current 14.5 million to an estimated 19 million in the next decade—the need to minimize chronic and late cancer treatment-related cognitive impairment becomes more urgent. Approximately one-third of patients with non-central nervous system malignancies treated with adjuvant chemotherapy experience clinically significant cognitive difficulties that persist for months or years following treatment. Survivors often report problems with memory, attention, verbal fluency, processing speed, multi-tasking, planning, and following directions.
The purpose of these FOAs is to encourage transdisciplinary research to improve traditional assessment of acute- and late-term cognitive changes following cancer treatment for non-central nervous system malignancies. Complaints of persistent cognitive deficits are common among the increasing population of cancer survivors, particularly those who have undergone adjuvant chemotherapy, hormone and/or molecularly-targeted cancer treatments. Systemically-treated cancer patients experience cognitive impairment during treatment, upon completion of regimens, and often as part of long-term survivorship. However, the specific nature and underlying mechanisms causing the cognitive impairments are often unclear. By leveraging advances in cognitive neuroscience, fundamental knowledge about the specific underlying mechanisms responsible for cognitive impairment may be obtained.
Task paradigms and tools developed in cognitive neuroscience in the last 30 years (e.g., cognitive neuroscience task paradigms, computational modeling, and electrophysiological techniques), have the potential to measure discrete cognitive processes and parse which subcomponent processes underlie cognitive complaints. In addition to their higher precision, these cognitive neuroscience paradigms may require considerably less time and are easier to administer than traditional clinical neuropsychological batteries, a significant potential asset for dissemination and implementation within the clinical setting.
The FOAs encourages transdisciplinary research projects that leverage advances in cognitive science, neuroscience and neuroimaging, and integrates expertise from diverse disciplines such as medical oncology, cancer epidemiology, neuropsychology, psychometrics, human development and aging, preclinical models of human cancer, statistical modeling, systems biology, genetics, and behavioral science.
Deadlines for submission for both the R01 and R21: October 10, 2017; April 11, 2018; October 10, 2018; April 11, 2019.
Neurosciences and the Department of Defense | APPLY NOW
The Congressionally Directed Medical Research Program (CDMRP) arose from a unique partnership among the U.S. Congress, the public, and the U.S. military. Success in managing the initial congressional appropriations in breast cancer, combined with the need for focused biomedical research, positioned the CDMRP into a principal funding organization for cancer research, military-relevant medical research, and other disease-specific research.
Hallmarks of the CDMRP include:
- Investing in groundbreaking research
- Targeting critical gaps
- Reviewing application using a two-tier formal review with no standing peer review panels and no "pay line"
- Involving consumer advocates throughout the program cycle
- Supporting both the next generation of researchers and established scientists
- Funding the full pipeline of research development, including basic, translational, and clinical research.
- Fostering (or employing) collaboration and synergy
The CDMRP fills research gaps by funding high impact, high risk and high gain projects that other agencies may not venture to fund. While individual programs are unique in their focus, all of the programs managed by the CDMRP share the common goal of advancing paradigm shifting research, solutions that will lead to cures or improvements in patient care, or breakthrough technologies and resources for clinical benefit. The CDMRP strives to transform healthcare for Service Members and the American public through innovative and impactful research.
Follow these links to learn more about open opportunities in these programs: Autism, Neurofibromatosis, Parkinson's, and Spinal Cord Injury.
RESEARCH, EDUCATION, AND OUTREACH
Cleared Concepts of Interest to NIA | GATHER IDEAS
The National Institute on Aging has posted the approved concepts here to give interested researchers maximal lead time to plan projects. Please note that not all concepts will necessarily end up converting to a Funding Opportunity Announcement. You can find brief summaries of the cleared concepts on the NIA website. Contact information for the NIA program staff involved with each concept is included. You will find that the award mechanism (R01, R21, or any of the 50 other mechanisms) or the funds allocated for a particular concept are not mentioned. Program staff cannot provide this information to you until the concept officially becomes an FOA. Award mechanisms and funding limits are determined when the FOAs are developed for publication in the NIH Guide.
Included in these concepts are:
Central neural mechanisms of age-related hearing loss – Given the significant emphasis placed on improving the accessibility of hearing aids and other assistive technologies to promote usage and adherence, it is timely for NIA to aid in this effort by stimulating research on age-related alterations in neural pathways, neural networks, and auditory system plasticity to inform these priorities.
Enhancing Central Neural Control of Mobility in Aging – Several major barriers exist for research on central neural control of mobility in aging. First, central nervous system (CNS) research on movement disorders has primarily centered on neurological diseases, whereas older adults with subclinical gait abnormalities have been largely ignored. The traditional disease-based models typically assumed that pathology is fairly localized, specific, and rapidly manifested. In contrast, in aging it is assumed that there is an accumulation of non-specific abnormalities that are distributed across the CNS, possibly over a long period of time. Second, disciplines studying mobility limitations often operate in silos and use multiple conceptual frameworks and terminologies that are largely discipline-specific with overlapping meanings but distinct definitions. This lack of coherence and common standards has limited the exchange of scientific findings across disciplines and the translational values from basic to clinical research. To overcome these barriers and to enhance central neural control of mobility in aging research, we need to develop an initiative that would enable collaboration of investigators from diverse disciplines.
Harmonizing Outcomes in Existing Cohorts to Enhance the Study of Risk and Protective Factors for Alzheimer's Disease and Alzheimer's Disease Related Dementias – The need to support data harmonization efforts across cohorts is not new, and substantial progress has been made for a variety of risk factors for AD/ADRD, which historically have been primary outcomes in other studies. Less progress has been made, however, in outcomes of highest relevance to the epidemiology of AD/ADRD, as well as resilience to these disease processes.
For more information see the NIA blog.
Carle Neuroscience Conference: Synapse | REGISTRATION NOW OPEN
Carle Foundation Hospital is pleased to announce the 2017 Neuroscience conference will be held on Friday, August 25, 2017, at The Forum at Carle in Urbana, Illinois. Registration is now open, so be sure to grab your spot!
The Neuroscience conference, renamed as "Synapse: A Collaborative Neuroscience Conference," is a multidisciplinary event that provides an education forum through which neuroscientists, physicians, faculty, researchers and ancillary providers can be recognized for their collaboration, engaged around future opportunities and provide a platform where care and research synergize. Synapse will encompass not only traditional neuroscience but also sleep medicine, back care, and epilepsy as it involves a merger of the Carle Neuroscience Institute (CNI) Update and the Carle Back Care Forum. Attendees have the option of selecting an afternoon breakout track (spine and non-spine) with a reception to follow the conference.
Fee: $50 (MD, DO, DC); $15 (residents and students); $25 (others)
Students attending this conference will receive a certificate of attendance but will not be issued continuing education credit for professional licensure. Should a student require continuing education credit for professional licensure, please be sure to register under the rate associated with the professional licensure.
Find more information and register here.
IMPORTANT DATES AND DEADLINES
- Synapse Conference: August 25, 2017
- NCI Application deadlines: October 10, 2017, April 11, 2018, October 10, 2018, April 11, 2019
- NSF DARE Application deadline: October 20, 2017
Please email Gillian Cooke, IHSI research development manager, with your calendar item or announcement to share with the clinical and translational neuroscience community at Illinois.