Nanoparticles are moving towards use as consumer products and therapeutic agents, and are gaining prevalence as environmental toxins. What happens when we inhale these nanoparticles? How will they interact with your lung tissue? With increasing concern about the impact that nanoparticles have on human health, I have taken an interest in the lung. The lung is the most susceptible region of the body to interact with environmental particulates. This image allows us to see the visual impacts of gold nanoparticles (yellow) on human lung endothelial cells. Each cellular nuclei (blue) is surrounded by the dynamic actin cytoskeleton (green). While these cells were once a continuous layer, the actin cytoskeleton has been remodeled in the presence of nanoparticles. Radial actin fibers are now outstretched between the gaps arising between the cells.