The relationship between influenza antigenic drift and vaccination is like the doomed love affair across time and space. Viruses are constantly flowing in nature, gradually accumulating mutations to escape the attack of antibodies; while antibodies are constantly updated to block viruses accurately. This moving story ends with a doomed encounter in the boundless star swirling. This imaging I created is good representation of my recent paper,“ Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing". Concept virions are constructed from Cinema 4D and the highlighted surface protein is H3N2 neuraminidase (NA).