The Mayo Clinic Center for Individualized Medicine is collaborating with the Coordinated Science Laboratory at the University of Illinois at Urbana-Champaign to unleash the potential of artificial intelligence in patient care. Funded by a National Science Foundation (NSF) grant, the Mayo Clinic and University of Illinois Alliance and corporate partners are conducting research into the big data challenge: how to develop computer systems that, combined with human intelligence, unlock new analysis of health and disease.