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  • Atomic structure of antifungal drug confirms unusual mechanism, opens door to less-toxic derivatives

    Dr. Martin Burke sits at a desk.

    Illinois chemistry professor Martin Burke co-led a team that mapped the unusual aggregate structure of the antifungal drug amphotericin B, illuminating the path to develop less-toxic forms of the drug.

    Photo by L. Brian Stauffer

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  • Editor’s notes: To reach Martin Burke, call 217-244-8726; email: mdburke@illinois.edu.  

    The paper “Fungicidal amphotericin B sponges are assemblies of staggered asymmetric homodimers encasing large void volumes” is available online.

    DOI: 10.1038/s41594-021-00685-4