Small molecule transports iron in mice, human cells to treat some forms of anemia Jun 24, 2022 9:00 am999 views A natural small molecule derived from a cypress tree can transport iron in live mice and human cells lacking the protein that normally does the job, easing a buildup of iron in the liver and restoring hemoglobin and red blood cell production, a new study found. Latin dance may be a step toward better working memory for older Latinos Jun 10, 2022 8:15 am1475 views Latin dance lessons may boost the working memory of Latino older adults and help prevent age-related cognitive decline, says new research by kinesiology and community health professor Susan Aguiñaga. SHIELD program a model for effective pandemic management, data show Jun 9, 2022 7:30 am3824 views In the fall of 2020, the University of Illinois Urbana-Champaign welcomed students back for in-person instruction amid the powerful first wave of the COVID-19 pandemic. The university successfully maintained operations throughout the semester – with zero COVID-19-related deaths or hospitalizations in the campus community – thanks to its “SHIELD: Target, Test, Tell” program. In a sweeping report, the team behind the campuswide collaboration details the innovations in modeling, saliva testing and results reporting that helped mitigate the spread of the virus, and shares the data collected and lessons learned through the process. Study tracks COVID-19 infection dynamics in adults Apr 28, 2022 10:00 am1062 views A team led by scientists at the University of Illinois Urbana-Champaign tracked the rise and fall of SARS-CoV-2 in the saliva and nasal cavities of people newly infected with the virus. The study was the first to follow acute COVID-19 infections over time through repeated sampling and to compare results from different testing methodologies. Machine-learning model can distinguish antibody targets Apr 21, 2022 1:30 pm937 views A new study shows that it is possible to use the genetic sequences of a person’s antibodies to predict what pathogens those antibodies will target. Reported in the journal Immunity, the new approach successfully differentiates between antibodies against influenza and those attacking SARS-CoV-2, the virus that causes COVID-19. Portable, point-of-care COVID-19 test discerns alpha variant from earlier strains Apr 19, 2022 11:30 am1472 views A point-of-care COVID-19 test developed by researchers at the University of Illinois Urbana-Champaign can now detect and differentiate the alpha variant of the SARS-CoV-2 virus from earlier strains in saliva samples. New approach enhances muscle recovery in aged mice Apr 13, 2022 8:00 am1428 views Scientists have developed a promising new method to combat the age-related losses in muscle mass that often accompany immobility after injury or illness. Their technique, demonstrated in mice, arrests the process by which muscles begin to deteriorate at the onset of exercise after a period of inactivity. Study: First-pass metabolism of alcohol occurs in women's stomachs Mar 22, 2022 8:45 am1359 views Research led by scientists at the University of Illinois Urbana-Champaign identifies the stomach, not the liver, as the site of alcohol first-pass metabolism in women who had sleeve gastrectomies and control-group peers. Team identifies compound with potent antiseizure effects Mar 22, 2022 8:00 am1257 views Researchers studying epileptic seizures of the temporal lobe – the most common type of epilepsy – discovered a compound that reduces seizures in the hippocampus, a brain region where many such seizures originate. The compound, known as TC-2153, lessened the severity of seizures in mice. Project helps East St. Louis residents overcome barriers to COVID-19 testing, vaccination Mar 11, 2022 8:15 am1318 views A project that is underway in East St. Louis, Illinois, is investigating strategies for overcoming barriers to COVID-19 testing and vaccination among more than 548 medically and socially vulnerable residents of St. Clair County. Team uses MRI to image epigenetics in the brain Feb 28, 2022 2:00 pm2665 views A multidisciplinary team at the University of Illinois Urbana-Champaign has devised a new approach to 3D imaging that captures DNA methylation, a key epigenetic change associated with learning in the brain. The scientists say their proof-of-concept study in pigs will easily translate to humans, as the new method relies on standard MRI technology and biological markers already in use in human medicine. Study identifies key regulator of cell differentiation Feb 21, 2022 2:00 pm1040 views Scientists have identified a molecule that regulates the fate of cells, switching off their ability to differentiate into distinct cell types. Oncology dietitians rarely ask cancer patients about food insecurity, study finds Feb 11, 2022 8:15 am914 views While many cancer survivors experience food insecurity, few oncology registered dietitians interviewed by U. of I. researchers indicated that they routinely screen their patients for it. Study: High COVID-19 rates in older Latinos linked with economics, outside help Feb 9, 2022 8:15 am548 views Financial hardship and outside help were significantly associated with COVID-19 diagnoses among older Latinos, University of Illinois Urbana-Champaign social work professor Lissette Piedra and her team found. Study: Lower acculturation linked with poorer cognitive function in older Hispanics Feb 9, 2022 8:00 am1099 views A new study on culture and cognition found that long-term Hispanic immigrants who were less acculturated to the U.S. performed significantly worse on cognitive function tests than their highly acculturated peers. New set of chemical building blocks makes complex 3D molecules in a snap Feb 8, 2022 10:00 am1090 views A new set of molecular building blocks aims to make complex chemistry as simple and accessible as a toy construction kit. Researchers at the University of Illinois Urbana-Champaign developed a new class of chemical building blocks that simply snap together to form 3D molecules with complex twists and turns, and an automated machine to assemble the blocks like a 3D printer for molecules. This automation could allow chemists and nonchemists alike to develop new pharmaceuticals, materials, diagnostic probes, catalysts, perfumes, sweeteners and more. Study: Telehealth services for the elderly should include caregivers Jan 24, 2022 4:30 pm638 views Family caregivers are often involved in the day-to-day activities of their older relatives, such as communicating with doctors, helping them navigate the health care system and making decisions that affect their care. When the pandemic hit, forcing health care systems to switch to telehealth visits, many of the caregivers who would have been involved in in-person care were left out of the process, according to a new observational study published in the Annals of Family Medicine. Overweight dogs respond well to high-protein, high-fiber diet Jan 24, 2022 9:00 am1529 views A study of overweight dogs fed a reduced calorie, high-protein, high-fiber diet for 24 weeks found that the dogs’ body composition and inflammatory markers changed over time in ways that parallel the positive changes seen in humans on similar diets. The dogs achieved a healthier weight without losing too much muscle mass, and their serum triglycerides, insulin and inflammatory markers all decreased with weight loss. CRISPR-Cas13 targets proteins causing ALS, Huntington's disease in the mouse nervous system Jan 19, 2022 1:15 pm5424 views A new study by University of Illinois Urbana-Champaign researchers used a targeted CRISPR technique in the central nervous systems of mice to turn off production of mutant proteins that can cause ALS and Huntington’s disease. Rather than the popular DNA-editing CRISPR-Cas9 technique, the new approach uses CRISPR-Cas13, which can target mRNA – the messenger molecule that carries protein blueprints transcribed from DNA. The Illinois team developed Cas13 systems that could target and cut RNAs that code for the proteins that trigger ALS and Huntington’s disease, effectively silencing the genes without disturbing the cell’s DNA. Does our place in society influence how we respond to COVID-19 protocol? Dec 23, 2021 11:15 am1523 views University of Illinois Urbana-Champaign electrical and computer engineering professor Lav Varshney is a co-author of a new study that explores how social capital influences choices regarding COVID-19 mitigation compliance. Illinois News Bureau physical sciences editor Lois Yoksoulian spoke with Varshney about the lessons learned from this study and how they may help in other public health crises. How can we identify, respond to pandemic-triggered mental health crises? Dec 23, 2021 7:30 am1230 views Social work professor Tara Powell discusses the U.S. surgeon general's recent advisory about a looming mental health crisis among the country's youths in the wake of the coronavirus pandemic. Models predict optimal airplane seating for reduced viral transmission Dec 21, 2021 9:45 am14843 views As airline ticket sales have soared during the holiday season and the omicron variant causes surges of COVID-19 cases, a new University of Illinois Urbana-Champaign study may help passengers and airlines reduce risk of COVID-19 transmission by optimally seating passengers to minimize potential virus spread. Researchers used the most current data on aerosol spread on airplanes to calculate optimal seating assignments for common Boeing aircraft at different capacities. Gene mutation leads to epileptic encephalopathy symptoms, neuron death in mice Dec 17, 2021 9:00 am1232 views Mice with a genetic mutation seen in patients with epileptic encephalopathy, a severe form of congenital epilepsy, exhibit not only the seizure, developmental and behavioral symptoms of the disorder, but also neural degeneration and inflammation in the brain, University of Illinois Urbana-Champaign researchers found in a new study. The findings highlight the mutation as an important part of the disease’s pathology and a potential target for treatment. Atomic structure of antifungal drug confirms unusual mechanism, opens door to less-toxic derivatives Dec 9, 2021 10:15 am963 views Advanced molecular imaging technology has now mapped the structure of a drug widely used to treat fungal infections but whose workings have mystified researchers and physicians for nearly 70 years. In a new study, researchers at the University of Illinois Urbana-Champaign, the University of Wisconsin, Madison and the National Institutes of Health described in atomistic detail the structure of the drug amphotericin B, a powerful but toxic antifungal agent. Seeing the structure provides illumination in the researchers’ quest to formulate less-toxic AmB derivatives. Water disinfection byproduct disrupts reproductive hormones, damages pituitary in female mice Nov 24, 2021 8:00 am875 views A byproduct formed during water disinfection disrupts hormones in the brain that regulate the female reproductive cycle in mice and also damages cells in the pituitary gland, a new study from University of Illinois Urbana-Champaign researchers found. The new study’s findings of the chemical’s effects on reproductive regulation in the brain complement previous work that found that it also disrupts function in and causes damage to ovary cells, indicating the chemical could impact the entire reproductive system. The researchers hope that the continued study of these effects can help establish a safe level of exposure to guide future regulations. PFAS exposure, high-fat diet drive prostate cells’ metabolism into pro-cancer state Nov 11, 2021 10:00 am1553 views Consuming a high-fat diet along with exposure to PFAS changes benign and malignant prostate cells, promoting rapid tumor growth, scientists at the University of Illinois found in mouse study. Scientists discover how antibiotics penetrate Gram-negative bacterial cell walls Nov 8, 2021 8:00 am2662 views Scientists have labored for decades to find antibiotics that work against Gram-negative bacteria, which cause some of the deadliest infections in hospital settings and are most likely to be resistant to treatment with existing antibiotics. In a study reported in the journal Chemical Science, researchers developed a new method to determine how antibiotics with specific chemical properties thread their way through tiny pores in the otherwise impenetrable cell envelopes of Gram-negative bacteria. Do kids need a COVID-19 vaccine? Nov 4, 2021 9:00 am1531 views The availability of a COVID-19 vaccine for school-aged children offers protection for children as well as eases challenges faced by their families and their schools, says Rebecca Lee Smith, an epidemiologist at the University of Illinois Urbana-Champaign. New molecule targets, images and treats lung cancer tumors in mice Oct 25, 2021 10:00 am1208 views Lung cancer can be elusive to spot and difficult to treat, but University of Illinois Urbana-Champaign researchers have developed a finely tuned molecular agent that can precisely target lung and other cancer cells for imaging and treatment. Patients view perinatal depression screenings as ineffective, study finds Oct 13, 2021 9:00 am1007 views A standardized protocol and patient-centered approach are needed to improve perinatal depression screenings so patients feel the screenings are useful and effective, a new study found. Wu earns NIH Director's New Innovator Award Oct 5, 2021 9:45 am3703 views Biochemistry professor Nicholas Wu has received a 2021 NIH Director’s New Innovator Award. His project aims to understand how antibodies interact with their targets. DNA sensor quickly determines whether viruses are infectious Sep 22, 2021 1:00 pm2915 views A new sensor can detect not only whether a virus is present, but whether it’s infectious – an important distinction for containing viral spread. Researchers demonstrated the sensor, which integrates specially designed DNA fragments and nanopore sensing, with two key viruses that cause infections worldwide: the human adenovirus and the virus that causes COVID-19. Antibodies from original strain COVID-19 infection don't bind to variants, study finds Sep 17, 2021 8:30 am6969 views People infected with the original strain of the virus that causes COVID-19 early in the pandemic produced a consistent antibody response, making two main groups of antibodies to bind to the spike protein on the virus’s outer surface. However, those antibodies don’t bind well to newer variants, a new study from the University of Illinois Urbana-Champaign found. Avocados change belly fat distribution in women, controlled study finds Sep 3, 2021 9:00 am42396 views An avocado a day could help redistribute belly fat in women toward a healthier profile, according to a new study from the University of Illinois Urbana-Champaign and collaborators. One hundred and five adults with overweight and obesity participated in a randomized controlled trial that provided one meal a day for 12 weeks. Women who consumed avocado as part of their daily meal had a reduction in deeper visceral abdominal fat. Can people take a livestock drug to treat a deadly virus? Sep 2, 2021 10:00 am36745 views Taking large or multiple doses of the anti-parasitic drug ivermectin can cause a toxic overdose, and humans should not take forms intended for animal use, says Illinois veterinary medicine expert Dr. Jim Lowe. Latinos' beliefs about social status may affect their cardiovascular health, study finds Aug 19, 2021 8:45 am733 views Subjective perceptions of their social status may have stronger effects on the cardiovascular health of Hispanics and Latinos in the U.S. than objective markers such as income, according to a new study led by Lissette Piedra. Light can trigger key signaling pathway for embryonic development, cancer Aug 17, 2021 12:45 pm3882 views Blue light is illuminating new understanding of a key signaling pathway in embryo development, tissue maintenance and cancer genesis. Illinois researchers developed a method that makes membrane-bound receptors reactive to light, triggering the Wnt pathway. Study: Domestic control of COVID-19 takes priority over international travel bans Aug 11, 2021 8:00 am895 views A new paper co-written by University of Illinois Urbana-Champaign economist Yilan Xu says taming domestic transmission of COVID-19 ought to be prioritized over international travel bans. Study identifies molecule that stimulates muscle-building Aug 9, 2021 8:00 am4659 views In a randomized control study of 10 healthy young men, researchers compared how consuming the single amino acid leucine or its two-molecule equivalent, dileucine, influenced muscle-building and breakdown. They found that dileucine boosts the metabolic processes that drive muscle growth 42% more than free leucine does. Study offers insight into underlying causes of seizure disorder in babies Aug 3, 2021 7:00 am890 views Researchers report that infantile spasms, a rare but serious seizure disorder in babies, appear to be the result of a molecular pathway gone awry. In their study of a mouse model of the disorder, the researchers discovered that genetic mutations associated with the disease impair a pathway that is involved in building new synapses in the hippocampus, a brain region essential to learning and memory. What impact do the Olympics and mass-sporting events have on public health? Aug 2, 2021 8:15 am2957 views Attending high-profile and mass-participation sporting events may increase individuals’ physical activity levels and enhance their emotional well-being, according to Mikihiro Sato, a professor of recreation, sport and tourism. Study tests microplasma against middle-ear infections Jul 29, 2021 8:00 am561 views In a new study, researchers explore the use of microplasma – a highly focused stream of chemically excited ions and molecules – as a noninvasive method for attacking the bacterial biofilms that resist antibiotic treatment in the middle ear. New approach eradicates breast cancer in mice Jul 21, 2021 1:00 pm26233 views A new approach to treating breast cancer kills 95-100% of cancer cells in mouse models of human estrogen-receptor-positive breast cancers and their metastases in bone, brain, liver and lungs. The newly developed drug, called ErSO, quickly shrinks even large tumors to undetectable levels. 2020 deadlier than previous five years, even with COVID-19 numbers removed, study finds Jul 19, 2021 1:30 pm2039 views An upswing in death rates from non-COVID-19 causes in 2020 hit hard for men ages 15-64, according to a new study by computer science professor Sheldon H. Jacobson and internal medicine professor Janet Jokela. University of Illinois receives APLU award for COVID-19 testing program Jul 1, 2021 2:00 pm2529 views The University of Illinois Urbana-Champaign has received the inaugural Research Response to Community Crisis Award from the Association of Public and Land-grant Universities for its COVID-19 testing program. Frequent COVID-19 testing key to efficient, early detection, study finds Jun 30, 2021 8:30 am2717 views The chance of detecting the virus that causes COVID-19 increases with more frequent testing, no matter the type of test, a new study found. Both polymerase chain reaction and antigen tests, paired with rapid results reporting, can achieve 98% sensitivity if deployed at least every three days. Consistent bedtime routines in infancy improve children's sleep habits through age 2 Jun 29, 2021 1:45 pm751 views Consistent bedtime routines and activities such as reading books beginning when infants are 3 months old promote better sleep habits through age 2, according to a study by researchers at the Family Resiliency Center. DNAzymes could outperform protein enzymes for genetic engineering Jun 24, 2021 8:15 am1642 views Move over, gene-editing proteins – there’s a smaller, cheaper, more specific genetic engineering tool on the block: DNAzymes – small DNA molecules that can function like protein enzymes. Researchers at the University of Illinois Urbana-Champaign have developed a technique that, for the first time, allows DNAzymes to target and cut double-stranded DNA, overcoming a significant limitation of the technology. Cancer survivors' tongues less sensitive to tastes than those of healthy peers Jun 23, 2021 9:15 am2479 views Head and neck cancer survivors' tongues are less sensitive to bitter, salty and sweet tastes, and this taste dysfunction lasts for years, University of Illinois Urbana-Champaign scientists found in a new study. Combining three techniques boosts brain-imaging precision Jun 23, 2021 7:00 am1207 views Researchers have developed a method to combine three brain-imaging techniques to more precisely capture the timing and location of brain responses to a stimulus.